Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | RBP4 | P02753 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313250 | 0.94 | HPGDS (0.37) | HPGDSTGFBR1TGFBR2KDM4ETDP1 | |
| SCHEMBL14313038 | 0.93 | HPGDS (0.35) | HPGDSKDM4ETDP1S1PR1S1PR3 | |
| SCHEMBL14312949 | 0.90 | HPGDS (0.34) | HPGDSTGFBR1TGFBR2KDM4EMAPT | |
| SCHEMBL14312866 | 0.90 | MAPK8 (0.34) | TGFBR1TGFBR2MAPTNPSR1MAPK8 | |
| SCHEMBL14312836 | 0.88 | TGFBR1 (0.32) | TGFBR1TGFBR2MAPK8MAPK9MAPK10 | |
| SCHEMBL14313200 | 0.87 | MAPK8 (0.32) | TGFBR1TGFBR2MAPK8MAPK9MAPK10 | |
| SCHEMBL14312830 | 0.86 | HPGDS (0.37) | HPGDSTGFBR1KDM4ENTRK1MAPT | |
| SCHEMBL14312884 | 0.86 | HPGDS (0.39) | HPGDSTGFBR1TGFBR2NTRK1MAPT | |
| SCHEMBL14313212 | 0.85 | MAPK8 (0.33) | TGFBR1TGFBR2MAPK8MAPK9MAPK10 | |
| SCHEMBL14313194 | 0.84 | HPGDS (0.36) | HPGDSTGFBR1TGFBR2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |