Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313158 | 0.93 | HPGDS (0.31) | HPGDSCES2 | |
| SCHEMBL14312794 | 0.90 | HPGDS (0.31) | HPGDSCES2 | |
| SCHEMBL14313210 | 0.89 | TGFBR1 (0.34) | TGFBR1CES2 | |
| SCHEMBL14312910 | 0.89 | HPGDS (0.40) | HPGDSCES2 | |
| SCHEMBL14312830 | 0.88 | HPGDS (0.37) | TGFBR1MAPTNPSR1HPGDSPOLB | |
| SCHEMBL14312982 | 0.87 | TGFBR1 (0.37) | TGFBR1HPGDSHPGDCES2 | |
| SCHEMBL14312866 | 0.87 | MAPK8 (0.34) | TGFBR1MAPTNPSR1 | |
| SCHEMBL14312735 | 0.85 | TGFBR1 (0.35) | TGFBR1HPGD | |
| SCHEMBL14312986 | 0.84 | TGFBR1 (0.35) | TGFBR1HPGD | |
| SCHEMBL14312554 | 0.82 | CES2 (0.30) | CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |