Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313194 | 0.93 | HPGDS (0.36) | HPGDSMAPK8MAPK9MAPK10TGFBR1 | |
| SCHEMBL14312659 | 0.92 | HPGDS (0.34) | HPGDSBCHEACHE | |
| SCHEMBL14312847 | 0.90 | HPGDS (0.36) | HPGDSMAPK8MAPK9MAPK10TGFBR1 | |
| SCHEMBL14313200 | 0.90 | MAPK8 (0.32) | MAPK8MAPK9MAPK10TGFBR1TGFBR2 | |
| SCHEMBL14312836 | 0.89 | TGFBR1 (0.32) | MAPK8MAPK9MAPK10TGFBR1TGFBR2 | |
| SCHEMBL14313453 | 0.88 | HPGDS (0.35) | HPGDSMAPK8MAPK9MAPK10BCHE | |
| SCHEMBL14312866 | 0.88 | MAPK8 (0.34) | MAPK8MAPK9MAPK10TGFBR1TGFBR2 | |
| SCHEMBL14313212 | 0.87 | MAPK8 (0.33) | MAPK8MAPK9MAPK10TGFBR1TGFBR2 | |
| SCHEMBL14313355 | 0.85 | TGFBR1 (0.35) | HPGDSMAPK8MAPK9MAPK10TGFBR1 | |
| SCHEMBL14313345 | 0.85 | HPGDS (0.35) | HPGDSBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |