Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313094 | 0.93 | TGFBR1 (0.35) | TGFBR1TGFBR2MAPTCYP2E1CYP3A4 | |
| SCHEMBL14312739 | 0.92 | SLC22A12 (0.33) | TGFBR1TGFBR2MAPTHPGDSSLC22A12 | |
| SCHEMBL14313271 | 0.88 | MAPT (0.33) | MAPTHPGDSSLC22A12 | |
| SCHEMBL14312949 | 0.85 | HPGDS (0.34) | TGFBR1TGFBR2MAPTCYP2E1CYP3A4 | |
| SCHEMBL14313107 | 0.84 | SLC22A12 (0.33) | TGFBR1TGFBR2HPGDSSLC22A12 | |
| SCHEMBL3226481 | 0.84 | HPGDS (0.46) | TGFBR1TGFBR2MAPTCYP2E1CYP3A4 | |
| SCHEMBL14313194 | 0.84 | HPGDS (0.36) | TGFBR1TGFBR2MAPTCYP2E1CYP3A4 | |
| SCHEMBL14313099 | 0.83 | TGFBR1 (0.36) | TGFBR1CYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL14313200 | 0.83 | MAPK8 (0.32) | TGFBR1TGFBR2MAPK8MAPK9MAPK10 | |
| SCHEMBL14312847 | 0.83 | HPGDS (0.36) | TGFBR1TGFBR2MAPTHPGDSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |