Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 6/20 | 0.50 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 3/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216424 | 0.86 | HPGDS (0.57) | HPGDSF2F10NTRK1NPSR1 | |
| SCHEMBL14313273 | 0.86 | HPGDS (0.58) | HPGDSGCKMEN1KMT2A | |
| SCHEMBL14312669 | 0.84 | HPGDS (0.45) | HPGDSF2TGFBR1KMT2AF12 | |
| SCHEMBL14312791 | 0.82 | NR3C2 (0.36) | HPGDS | |
| SCHEMBL14313100 | 0.80 | HPGDS (0.47) | HPGDSF2F10KMT2AF12 | |
| SCHEMBL3213062 | 0.78 | HPGDS (0.80) | HPGDSF2F10NPSR1TGFBR1 | |
| SCHEMBL14312654 | 0.76 | HPGDS (0.39) | HPGDSF2KMT2AF12 | |
| SCHEMBL14313083 | 0.76 | HPGDS (0.68) | HPGDSF2F10NPSR1KMT2A | |
| SCHEMBL14313213 | 0.74 | KDM4A (0.42) | HPGDSADORA2A | |
| SCHEMBL14312771 | 0.71 | GRIN2B (0.38) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |