Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 2/20 | 0.37 |
| ▸ | GUSB | P08236 | 2/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313117 | 0.88 | HPGDS (0.38) | HPGDSLMNAMAPTKMT2A | |
| SCHEMBL14312669 | 0.87 | HPGDS (0.45) | HPGDSF2F12MAPTRAB9A | |
| SCHEMBL14313445 | 0.87 | HPGDS (0.54) | HPGDSL3MBTL1F2GLAKLKB1 | |
| SCHEMBL12083928 | 0.86 | HPGDS (0.54) | HPGDSGRM4L3MBTL1F2F12 | |
| SCHEMBL14313213 | 0.85 | KDM4A (0.42) | HPGDSGAA | |
| SCHEMBL14312729 | 0.84 | MET (0.39) | HPGDS | |
| SCHEMBL14313102 | 0.82 | HPGDS (0.48) | HPGDSL3MBTL1F2F12CTSD | |
| SCHEMBL14313083 | 0.81 | HPGDS (0.68) | HPGDSGRM4L3MBTL1F2CTSD | |
| SCHEMBL14313040 | 0.80 | HPGDS (0.50) | HPGDSF2F12GLAKLKB1 | |
| SCHEMBL14312654 | 0.80 | HPGDS (0.39) | HPGDSF2F12MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |