Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | F12 | P00748 | 3/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312669 | 0.87 | HPGDS (0.45) | HPGDSF2F12PLAUNPC1 | |
| SCHEMBL14312671 | 0.85 | HPGDS (0.46) | HPGDSSLC22A12MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3222378 | 0.85 | HPGDS (0.49) | HPGDSENPP1PARP1F2F12 | |
| SCHEMBL14312890 | 0.81 | SLC22A12 (0.37) | HPGDSPARP1SLC22A12 | |
| SCHEMBL14313100 | 0.80 | HPGDS (0.47) | HPGDSF2F12MAPTRAB9A | |
| SCHEMBL14313213 | 0.77 | KDM4A (0.42) | HPGDSABCG2 | |
| SCHEMBL3221680 | 0.77 | HPGDS (0.63) | HPGDSENPP1PARP1SLC22A12MTNR1A | |
| SCHEMBL14313040 | 0.76 | HPGDS (0.50) | HPGDSF2F12KMT2A | |
| SCHEMBL14313256 | 0.73 | HPGDS (0.52) | HPGDSMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL14313022 | 0.73 | HPGDS (0.45) | HPGDSMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |