Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | GUSB | P08236 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | F12 | P00748 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313023 | 0.89 | HPGDS (0.51) | HPGDSHRH3L3MBTL1RAB9ALMNA | |
| SCHEMBL12083668 | 0.87 | HPGDS (0.52) | HPGDSHRH3L3MBTL1CTSDGUSB | |
| SCHEMBL14312733 | 0.85 | CSNK1D (0.39) | HPGDSF10 | |
| SCHEMBL14312954 | 0.85 | CYP11B1 (0.39) | HPGDSLMNAMAPTKMT2AF2 | |
| SCHEMBL14313100 | 0.82 | HPGDS (0.47) | HPGDSL3MBTL1CTSDGUSBRAB9A | |
| SCHEMBL12083712 | 0.82 | HPGDS (0.68) | HPGDSHRH3L3MBTL1CTSDGUSB | |
| SCHEMBL14313083 | 0.80 | HPGDS (0.68) | HPGDSHRH3L3MBTL1CTSDGUSB | |
| SCHEMBL14312850 | 0.79 | CSNK1D (0.39) | HPGDSMAPT | |
| SCHEMBL14312871 | 0.75 | HPGDS (0.40) | HPGDSLMNAMAPTKCNH2F10 | |
| SCHEMBL14313176 | 0.75 | LMNA (0.39) | HPGDSLMNAMAPTKMT2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |