Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 2/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313001 | 0.88 | HPGDS (0.43) | HPGDSAKR1A1AKR1B1PDE4APDE4B | |
| SCHEMBL12084154 | 0.86 | HPGDS (0.46) | MAPK9MAPK8MAPK10HPGDSCCR2 | |
| SCHEMBL14313274 | 0.86 | HPGDS (0.33) | HPGDS | |
| SCHEMBL14313161 | 0.85 | HPGDS (0.48) | HPGDSNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL14312960 | 0.83 | HPGDS (0.36) | MAPK9MAPK8MAPK10HPGDSSCN9A | |
| SCHEMBL14312398 | 0.83 | HPGDS (0.38) | HPGDS | |
| SCHEMBL14313349 | 0.83 | HPGDS (0.32) | MAPK9MAPK8MAPK10HPGDS | |
| SCHEMBL14313003 | 0.82 | HPGDS (0.39) | HPGDS | |
| SCHEMBL14313030 | 0.81 | MAPK8 (0.33) | MAPK9MAPK8MAPK10HPGDS | |
| SCHEMBL14312951 | 0.81 | HPGDS (0.38) | HPGDSS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |