Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.46 |
| ▸ | KLK1 | P06870 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | MASP2 | O00187 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1432922 | 0.90 | KLKB1 (0.49) | KLKB1KLK1MMP2MMP9MMP8 | |
| SCHEMBL1431611 | 0.81 | KLKB1 (0.40) | KLKB1KLK1MASP2MMP1NAMPT | |
| SCHEMBL1906443 | 0.79 | KLKB1 (0.50) | KLKB1KLK1MMP2MMP9MMP8 | |
| SCHEMBL3154586 | 0.75 | MASP2 (0.47) | KLKB1KLK1MASP2TP53SMN1; SMN2 | |
| SCHEMBL1431845 | 0.73 | MME (0.51) | KLKB1MMP2MMP9MMP8CTSS | |
| SCHEMBL1432848 | 0.73 | KLKB1 (0.47) | KLKB1KLK1MMP2MMP9MMP8 | |
| SCHEMBL1431493 | 0.73 | MASP2 (0.46) | KLKB1KLK1MASP2NAMPT | |
| SCHEMBL1433656 | 0.72 | KLKB1 (0.46) | KLKB1KLK1CTSLCTSSCTSK | |
| SCHEMBL1432298 | 0.72 | CTSK (0.53) | CTSSCTSK | |
| SCHEMBL1432297 | 0.72 | CTSK (0.53) | CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300428-A1 | AMINOPYRIDINE DERIVATIVES | Vantia Limited (GB) | 2011-03-30 | — | — | EP | disclosed |