Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.44 |
| ▸ | CDK8 | P49336 | 4/20 | 0.43 |
| ▸ | CLK2 | P49760 | 3/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | HIPK4 | Q8NE63 | 5/20 | 0.40 |
| ▸ | SRPK1 | Q96SB4 | 4/20 | 0.40 |
| ▸ | STK3 | Q13188 | 4/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14308049 | 0.91 | CLK4 (0.45) | GRM5CLK4ACVR1CDK8CLK2 | |
| SCHEMBL12102188 | 0.85 | ACVR1 (0.47) | GRM5CLK4ACVR1CDK8CLK2 | |
| SCHEMBL14309232 | 0.84 | CLK4 (0.41) | GRM5CLK4ACVR1CDK8CLK2 | |
| SCHEMBL14319138 | 0.83 | HCRTR1 (0.41) | GRM5CLK4ACVR1CDK8CLK2 | |
| SCHEMBL1464871 | 0.79 | CNR2 (0.55) | GRM5CLK4ACVR1CDK8CLK2 | |
| SCHEMBL13842703 | 0.78 | RORC (0.48) | GRM5CLK4ACVR1CDK8CLK2 | |
| SCHEMBL1464316 | 0.76 | GSK3A (0.49) | GRM5CLK4ACVR1CDK8CLK2 | |
| SCHEMBL12102167 | 0.74 | GRM5 (0.51) | GRM5CLK4ACVR1CDK8CLK2 | |
| SCHEMBL14960342 | 0.74 | GSK3A (0.48) | GRM5CLK4ACVR1CDK8CLK2 | |
| SCHEMBL14319141 | 0.73 | NPC1 (0.48) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008014199-A2 | SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-01-31 | — | — | WO | disclosed |