Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 10/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.47 |
| ▸ | CDK8 | P49336 | 5/20 | 0.46 |
| ▸ | CLK2 | P49760 | 4/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 7/20 | 0.43 |
| ▸ | GSK3B | P49841 | 7/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14319140 | 0.85 | GRM5 (0.48) | ACVR1CLK4CDK8CLK2DYRK1B | |
| SCHEMBL14308049 | 0.79 | CLK4 (0.45) | ACVR1CLK4CDK8CLK2DYRK1B | |
| SCHEMBL14319138 | 0.79 | HCRTR1 (0.41) | ACVR1CLK4CDK8CLK2DYRK1B | |
| SCHEMBL1464042 | 0.77 | ACVR1 (0.47) | ACVR1CLK4CDK8CLK2DYRK1B | |
| SCHEMBL12102170 | 0.76 | NPC1 (0.46) | MEN1KMT2A | |
| SCHEMBL13842703 | 0.75 | RORC (0.48) | ACVR1CLK4CDK8CLK2DYRK1B | |
| SCHEMBL1464446 | 0.75 | ACVR1 (0.47) | ACVR1CLK4CDK8CLK2DYRK1B | |
| SCHEMBL14300149 | 0.75 | CLK4 (0.50) | ACVR1CLK4CDK8CLK2DYRK1B | |
| SCHEMBL14309232 | 0.74 | CLK4 (0.41) | ACVR1CLK4CDK8CLK2DYRK1B | |
| SCHEMBL14960342 | 0.74 | GSK3A (0.48) | ACVR1CLK4CDK8CLK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081905-B1 | SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INT (DE) | 2012-09-12 | — | — | EP | disclosed |
| WO-2008014199-A2 | SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-01-31 | — | — | WO | disclosed |