Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxycodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 0.79 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.79 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.76 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxycodone SCHEMBL4222853 | 0.99 | OPRM1 (0.79) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxycodone SCHEMBL3407528 | 0.96 | OPRM1 (0.73) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxycodone SCHEMBL7570264 | 0.91 | OPRM1 (0.65) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxycodone SCHEMBL28142074 | 0.90 | OPRM1 (0.73) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxymorphone SCHEMBL7049111 | 0.89 | OPRM1 (0.77) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxycodone SCHEMBL2029377 | 0.89 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL18395933 | 0.89 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL30095 | 0.89 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL1134895 | 0.89 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL15549172 | 0.89 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120330012-A1 | Novel Tricyclic Compounds | ABBOTT LABORATORIES (US) | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120330012-A1 | Novel Tricyclic Compounds | CYP11B2, CYP11B1, ABCB1 | OPRM1 357/4885OPRD1 560/4885OPRK1 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.