Oxycodone

SCHEMBL7570264

COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314.COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1

The experimentally established mechanism targets of Oxycodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	OPRM1 known ✓	P35372	11/20	0.65

▸	OPRD1	P41143	8/20	0.65

▸	OPRK1	P41145	8/20	0.65

▸	MRGPRX2	Q96LB1	3/20	0.64

▸	PDE4D	Q08499	2/20	0.64

▸	LMNA	P02545	2/20	0.64

▸	ADRB1	P08588	1/20	0.63

▸	PDE3A	Q14432	1/20	0.63

▸	ALDH1A1	P00352	1/20	0.56

▸	CYP3A4	P08684	1/20	0.56

▸	CYP2D6	P10635	1/20	0.56

▸	TSHR	P16473	1/20	0.56

▸	HSD17B10	Q99714	1/20	0.56

▸	BLM	P54132	1/20	0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Oxycodone SCHEMBL19285728	0.97	OPRM1 (0.61)	OPRM1OPRD1OPRK1MRGPRX2PDE4D
Oxycodone SCHEMBL17165053	0.97	OPRM1 (0.61)	OPRM1OPRD1OPRK1MRGPRX2PDE4D
Oxycodone SCHEMBL4588570	0.95	OPRM1 (0.73)	OPRM1OPRD1OPRK1MRGPRX2PDE4D
Oxycodone SCHEMBL19463262	0.95	OPRM1 (0.59)	OPRM1OPRD1OPRK1MRGPRX2PDE4D
Oxycodone SCHEMBL19285721	0.93	OPRM1 (0.57)	OPRM1OPRD1OPRK1MRGPRX2PDE4D
Oxycodone SCHEMBL1029465	0.92	OPRM1 (0.68)	OPRM1OPRD1OPRK1MRGPRX2PDE4D
Oxymorphone SCHEMBL1828172	0.92	OPRM1 (0.68)	OPRM1OPRD1OPRK1MRGPRX2PDE4D
Oxycodone SCHEMBL4222853	0.91	OPRM1 (0.79)	OPRM1OPRD1OPRK1MRGPRX2PDE4D
Oxycodone SCHEMBL14320307	0.91	OPRM1 (0.79)	OPRM1OPRD1OPRK1MRGPRX2PDE4D
Hydrocodone SCHEMBL1359279	0.91	OPRM1 (0.78)	OPRM1OPRD1OPRK1MRGPRX2PDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1235618-A2	BIOCONJUGATION IN VIVO TO PULMONARY OR BLOOD COMPONENTS	Conjuchem, Inc. (CA)	2002-09-04	—	—	EP	disclosed
WO-2001017568-A2	BIOCONJUGATION IN VIVO TO PULMONARY OR BLOOD COMPONENTS	CONJUCHEM, INC. (CA)	2001-03-15	—	—	WO	disclosed