Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418996 | 0.86 | GAA (0.57) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL27768478 | 0.84 | CHRNB2 (0.63) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL1815822 | 0.82 | CHRNB2 (0.61) | MKNK1MKNK2CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL12377814 | 0.78 | GAA (0.54) | SMN1; SMN2NPC1TP53RAB9AMAPT | |
| SCHEMBL3419014 | 0.77 | NPC1 (0.52) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL7659667 | 0.77 | HTT (0.60) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL16383885 | 0.75 | SMPD1 (0.57) | SMN1; SMN2NPC1TP53RAB9AKDM4E | |
| SCHEMBL14427066 | 0.74 | NPC1 (0.47) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL1766056 | 0.74 | TP53 (0.58) | SMN1; SMN2NPC1TP53RAB9AGSK3B | |
| SCHEMBL12251213 | 0.73 | MKNK1 (1.00) | MKNK1MKNK2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300470-A2 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS GABA-A RECEPTOR MODULATORS | Sepracor Inc. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009143156-A2 | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS | SEPRACOR INC. (US) | 2009-11-26 | — | — | WO | disclosed |