Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699155 | 0.92 | NPC1 (0.47) | NPC1RAB9ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL14323123 | 0.90 | NPC1 (0.41) | NPC1RAB9ALMNAPOLBBCL2 | |
| SCHEMBL14324126 | 0.89 | NPC1 (0.44) | NPC1RAB9ALMNAPOLBTP53 | |
| SCHEMBL11352183 | 0.89 | NPC1 (0.40) | NPC1RAB9ALMNAPOLBTP53 | |
| SCHEMBL9468547 | 0.88 | NPC1 (0.40) | NPC1RAB9ALMNAPOLBBCL2 | |
| SCHEMBL23246318 | 0.87 | NPC1 (0.47) | NPC1RAB9ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL14323852 | 0.86 | NPC1 (0.37) | NPC1RAB9ALMNAPOLBTP53 | |
| SCHEMBL8962454 | 0.86 | NPC1 (0.54) | NPC1RAB9ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL3077803 | 0.86 | HSPA5 (0.42) | NPC1RAB9ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL30388311 | 0.85 | NPC1 (0.42) | NPC1RAB9ALMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120329885-A1 | Ultraviolet light absorbing compounds based on benzyl substituted 2-(2- hydroxyphenyl) benzotriazoles | CHANG CHIA-HU (US) | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329885-A1 | Ultraviolet light absorbing compounds based on benzyl substituted 2-(2- hydroxyphenyl) benzotriazoles | AHR, ARNT, BCAT1 | NPC1 3659/4885RAB9A 4167/4885LMNA 1797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.