Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16403987 | 0.93 | RAB9A (0.50) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL14315443 | 0.82 | RAB9A (0.63) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL16404071 | 0.82 | RAB9A (0.40) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL16403920 | 0.82 | ALDH1A1 (0.38) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL16404150 | 0.82 | RAB9A (0.42) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL14224988 | 0.80 | RAB9A (0.41) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL14224974 | 0.79 | ALDH1A1 (0.39) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL14224958 | 0.78 | ALDH1A1 (0.43) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL16403981 | 0.78 | RAB9A (0.43) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL16404062 | 0.77 | NPC1 (0.54) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| WO-2012172438-A9 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2013-02-07 | — | — | WO | disclosed |
| WO-2012172438-A2 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2012-12-20 | — | — | WO | disclosed |