Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327086 | 0.80 | RIPK1 (0.36) | RIPK1TYRO3 | |
| SCHEMBL14312813 | 0.79 | ACVRL1 (0.43) | RIPK1ACVRL1 | |
| SCHEMBL14327061 | 0.77 | ACVRL1 (0.36) | RIPK1ACVRL1 | |
| SCHEMBL14313204 | 0.76 | TYRO3 (0.40) | RIPK1TYRO3 | |
| SCHEMBL14313236 | 0.76 | ACVRL1 (0.47) | RIPK1ACVRL1MERTK | |
| SCHEMBL14313008 | 0.75 | TYRO3 (0.41) | RIPK1TYRO3MERTK | |
| SCHEMBL14327055 | 0.75 | TYRO3 (0.39) | RIPK1TYRO3MERTK | |
| SCHEMBL14327087 | 0.74 | TYRO3 (0.43) | RIPK1ACVRL1TYRO3AXLMERTK | |
| SCHEMBL5077843 | 0.74 | ADORA3 (0.38) | RIPK1ACVRL1 | |
| SCHEMBL14312579 | 0.74 | ACVRL1 (0.45) | RIPK1ACVRL1TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-B1 | PYRROLO[2,1-F] [1,2,4]-TRIAZIN-4-YLAMINES AS IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer Pharma AG (DE) | 2012-12-26 | — | — | EP | disclosed |