Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 18/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327061 | 0.87 | ACVRL1 (0.36) | RIPK1RETKDR | |
| SCHEMBL14312813 | 0.81 | ACVRL1 (0.43) | RIPK1RETKDR | |
| SCHEMBL14327088 | 0.80 | RIPK1 (0.34) | RIPK1TYRO3 | |
| SCHEMBL14531789 | 0.79 | CFTR (0.34) | RIPK1 | |
| SCHEMBL14327068 | 0.79 | RIPK1 (0.37) | RIPK1RETKDR | |
| SCHEMBL14312500 | 0.78 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL14313418 | 0.77 | PIK3CD (0.45) | RIPK1 | |
| SCHEMBL14531365 | 0.77 | RIPK1 (0.46) | RIPK1 | |
| SCHEMBL16496878 | 0.76 | RIPK1 (0.43) | RIPK1 | |
| SCHEMBL14312723 | 0.76 | RIPK1 (0.46) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-B1 | PYRROLO[2,1-F] [1,2,4]-TRIAZIN-4-YLAMINES AS IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer Pharma AG (DE) | 2012-12-26 | — | — | EP | disclosed |