Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14334240 | 0.86 | CYP4A11 (0.49) | CYP4A11CYP4F2CYP1A2 | |
| SCHEMBL14334120 | 0.86 | ROCK2 (0.48) | ROCK2 | |
| SCHEMBL14335146 | 0.82 | CYP4F2 (0.49) | ROCK2CYP4A11CYP4F2CHEK2 | |
| SCHEMBL14334926 | 0.81 | ROCK2 (0.46) | ROCK2 | |
| SCHEMBL14334913 | 0.81 | ROCK2 (0.48) | ROCK2 | |
| SCHEMBL23458839 | 0.80 | ROCK2 (0.53) | ROCK2 | |
| SCHEMBL18525521 | 0.77 | IRAK4 (0.69) | — | |
| SCHEMBL14335160 | 0.76 | PIK3CD (0.47) | — | |
| SCHEMBL14334294 | 0.74 | IRAK4 (0.60) | ROCK2CYP4A11CYP4F2CHEK2 | |
| SCHEMBL20646783 | 0.74 | RAB9A (0.48) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012176123-A1 | 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2012-12-27 | — | — | WO | disclosed |