Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14334239 | 0.86 | ROCK2 (0.50) | CYP4A11CYP4F2CYP1A2 | |
| SCHEMBL14334436 | 0.85 | PIK3CD (0.48) | — | |
| SCHEMBL2406917 | 0.85 | PIK3CD (0.48) | — | |
| SCHEMBL2406918 | 0.85 | PIK3CD (0.48) | — | |
| SCHEMBL14334122 | 0.85 | — | — | |
| SCHEMBL12279675 | 0.85 | DGAT2 (0.42) | CYP4A11CYP4F2NAMPT | |
| SCHEMBL14335148 | 0.81 | CYP4F2 (0.51) | CYP4A11CYP4F2PDE10AHTR2ATMEM97 | |
| SCHEMBL14334914 | 0.80 | NAMPT (0.45) | NAMPT | |
| SCHEMBL14334929 | 0.80 | KDM5A (0.40) | — | |
| SCHEMBL1936648 | 0.78 | GRM4 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012176123-A1 | 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2012-12-27 | — | — | WO | disclosed |