Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14334913 | 0.86 | ROCK2 (0.48) | NAMPTHMOX1 | |
| SCHEMBL14334929 | 0.86 | KDM5A (0.40) | KDM5AGPR119 | |
| SCHEMBL14334113 | 0.82 | PIK3CD (0.55) | PIK3CDPIK3CAGPR119 | |
| SCHEMBL14377360 | 0.82 | PIK3CD (0.55) | PIK3CDPIK3CAGPR119 | |
| SCHEMBL14334122 | 0.82 | — | — | |
| SCHEMBL14334240 | 0.80 | CYP4A11 (0.49) | NAMPT | |
| SCHEMBL14335162 | 0.79 | PIK3CD (0.50) | PIK3CDPIK3CA | |
| SCHEMBL1936648 | 0.77 | GRM4 (0.38) | — | |
| SCHEMBL14335009 | 0.77 | GPR119 (0.54) | PIK3CDGPR119 | |
| SCHEMBL14334436 | 0.76 | PIK3CD (0.48) | PIK3CDPIK3CAGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012176123-A1 | 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2012-12-27 | — | — | WO | disclosed |