Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14335160 | 0.87 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3R1 | |
| SCHEMBL14334929 | 0.79 | KDM5A (0.40) | — | |
| SCHEMBL14334914 | 0.79 | NAMPT (0.45) | PIK3CDPIK3CA | |
| SCHEMBL14377360 | 0.77 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14334113 | 0.77 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29445482 | 0.77 | GRM4 (0.53) | — | |
| SCHEMBL1936639 | 0.77 | GRM4 (0.53) | — | |
| SCHEMBL14334122 | 0.77 | — | — | |
| SCHEMBL31234741 | 0.76 | NAMPT (0.44) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14334240 | 0.75 | CYP4A11 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012176123-A1 | 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2012-12-27 | — | — | WO | disclosed |