Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14335736 | 1.00 | L3MBTL1 (0.41) | L3MBTL1ATMCHRM3KMT2AMEN1 | |
| SCHEMBL14335739 | 1.00 | L3MBTL1 (0.41) | L3MBTL1ATMCHRM3KMT2AMEN1 | |
| SCHEMBL14375625 | 0.85 | FPR2 (0.49) | KMT2AMEN1CHRNA7HPGDALDH1A1 | |
| SCHEMBL15675293 | 0.85 | FPR2 (0.49) | KMT2AMEN1CHRNA7HPGDALDH1A1 | |
| SCHEMBL15675294 | 0.85 | FPR2 (0.49) | KMT2AMEN1CHRNA7HPGDALDH1A1 | |
| SCHEMBL28775623 | 0.79 | REN (0.45) | L3MBTL1ATMCHRM3ALDH1A1GAA | |
| SCHEMBL28775622 | 0.79 | REN (0.45) | L3MBTL1ATMCHRM3ALDH1A1GAA | |
| SCHEMBL23089076 | 0.75 | ALDH1A1 (0.35) | L3MBTL1ATMCHRM3KMT2AALDH1A1 | |
| SCHEMBL14376208 | 0.75 | CYP19A1 (0.42) | CHRM3KMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL28240876 | 0.73 | CYP2D6 (0.38) | KMT2ACYP2D6ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721008-A1 | HYDROXY SUBSTITUTED ISOQUINOLINONE DERIVATIVES | Novartis AG (CH) | 2014-04-23 | — | — | EP | disclosed |
| WO-2012175520-A1 | HYDROXY SUBSTITUTED ISOQUINOLINONE DERIVATIVES | NOVARTIS AG (CH) | 2012-12-27 | — | — | WO | disclosed |