SCHEMBL14345736

SCHEMBL14345736

Cc1c2n(cnc1=O)CCc1c-2n(C)c2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
TSHR P16473 1/20 0.47
MAOA P21397 4/20 0.43
MAPT P10636 1/20 0.42
ALOX15 P16050 1/20 0.42
MAPK1 P28482 1/20 0.42
PDE5A O76074 4/20 0.41
MAOB P27338 1/20 0.40
GSK3A P49840 2/20 0.40
GSK3B P49841 2/20 0.40
CDK5 Q00535 1/20 0.40
CDK5R1 Q15078 1/20 0.40
CYP1A2 P05177 2/20 0.38
CYP3A4 P08684 1/20 0.38
ADRA2C P18825 1/20 0.38
HTR2A P28223 1/20 0.38
HTR2C P28335 1/20 0.38
ADRA1A P35348 1/20 0.38
HTR2B P41595 1/20 0.38
HTR3A P46098 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14345726 0.78 ALDH1A1 (0.47) ALDH1A1TSHRMAOAMAPTALOX15
SCHEMBL14345747 0.75 CYP1A1 (0.51) ALDH1A1TSHRMAPTPDE5ACYP1A2
SCHEMBL14345759 0.71 ALDH1A1 (0.48) ALDH1A1TSHRMAOAMAPTALOX15
SCHEMBL8792194 0.69 ALDH1A1 (0.62) ALDH1A1TSHRMAOAMAPTALOX15
SCHEMBL14425146 0.68 MAOA (0.46) ALDH1A1TSHRMAOAMAPTALOX15
SCHEMBL14345925 0.67 PDE5A (0.47) ALDH1A1TSHRMAOAMAPTALOX15
SCHEMBL30223561 0.66 KDM4E (0.66) ALDH1A1TSHRMAOAMAPTALOX15
SCHEMBL22118133 0.66 KDM4E (0.66) ALDH1A1TSHRMAOAMAPTALOX15
SCHEMBL17895740 0.66 KDM4E (0.61) ALDH1A1TSHRMAOAMAPTALOX15
SCHEMBL14345741 0.65 CYP1A2 (0.57) ALDH1A1TSHRMAOAMAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007138081-A1 PYRIMIDINO[1',6'-1,2]PYRIDO[3,4-b]INDOLE DERIVATIVES AND THEIR THERAPEUTIC USAGE FOURTILLAN (FR) 2007-12-06 WO disclosed