Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13552125 | 0.85 | JAK2 (0.50) | LRRK2IKBKBPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL14346059 | 0.83 | MITF (0.43) | PRKAA1JAK2TYK2JAK3GSK3B | |
| SCHEMBL14385066 | 0.82 | MAP2K4 (0.49) | LRRK2IKBKBPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL11911445 | 0.80 | JAK2 (0.55) | LRRK2IKBKBPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL14368882 | 0.79 | JAK2 (0.51) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL1142184 | 0.74 | JAK2 (0.54) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| Hydrochloric Acid SCHEMBL1142099 | 0.73 | JAK2 (0.53) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL2054572 | 0.72 | PRKAG1 (0.55) | LRRK2PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL23029783 | 0.72 | PRKAG1 (0.54) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL30587498 | 0.71 | MAP2K4 (0.65) | IKBKBJAK3GSK3BMAP2K4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293499-A1 | Intracellular Kinase Inhibitors | MANNKIND CORPORATION (US) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293499-A1 | Intracellular Kinase Inhibitors | PI4KB, BTK, LTK | LRRK2 917/4885IKBKB 107/4885PRKAG1 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.