Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | TYK2 | P29597 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23029783 | 0.86 | PRKAG1 (0.54) | GSK3BKIF11PRKAA1PRKAB2PRKAG1 | |
| SCHEMBL14346062 | 0.85 | LRRK2 (0.47) | JAK2TYK2JAK3JAK1LRRK2 | |
| SCHEMBL11916132 | 0.82 | KDM4E (0.60) | GSK3BSMN1; SMN2KIF11CHEK1PRKAA1 | |
| SCHEMBL11911445 | 0.80 | JAK2 (0.55) | JAK2TYK2JAK3JAK1LRRK2 | |
| SCHEMBL15541582 | 0.80 | JAK2 (0.53) | JAK2TYK2JAK3JAK1MAP2K4 | |
| SCHEMBL15077179 | 0.79 | KDM4E (0.63) | GSK3BSMN1; SMN2KIF11MAPK1 | |
| SCHEMBL28258656 | 0.79 | CHEK1 (0.53) | JAK2TYK2JAK3JAK1CHEK1 | |
| SCHEMBL8877902 | 0.78 | JAK1 (0.65) | JAK2TYK2JAK3JAK1GSK3B | |
| SCHEMBL84515 | 0.77 | PDPK1 (0.55) | JAK2TYK2JAK3GSK3BKIF11 | |
| SCHEMBL16252829 | 0.76 | MAP2K4 (0.52) | JAK2TYK2JAK3JAK1MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336958-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2015-11-26 | — | — | US | disclosed |
| US-20150112068-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2015-04-23 | — | — | US | disclosed |
| US-20140323730-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER (US) | 2014-10-30 | — | — | US | disclosed |
| US-8802688-B2 | Substituted acetyl-coa carboxylase inhibitors | PFIZER INC. (US) | 2014-08-12 | — | — | US | disclosed |
| US-20120270893-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336958-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | JAK2 1871/4885TYK2 4262/4885JAK3 3792/4885 |
| US-20150112068-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | JAK2 1871/4885TYK2 4262/4885JAK3 3792/4885 |
| US-20140323730-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | JAK2 1917/4885TYK2 4259/4885JAK3 3848/4885 |
| US-20120270893-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | JAK2 1917/4885TYK2 4259/4885JAK3 3848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.