Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1547465 | 0.79 | ALDH1A1 (0.41) | CA2LMNAALDH1A1 | |
| SCHEMBL7219392 | 0.75 | MAPT (0.65) | EGFRTNNI3KFBP1PGRKAT6A | |
| SCHEMBL22681223 | 0.73 | KAT6A (0.42) | EGFRTNNI3KFBP1PGRKAT6A | |
| SCHEMBL12278151 | 0.73 | TNNI3K (0.62) | EGFRTNNI3KFBP1PGRKAT6A | |
| SCHEMBL1548097 | 0.72 | GAA (0.47) | SMN1; SMN2HPGDCA2KDM4EMEN1 | |
| SCHEMBL12089569 | 0.71 | CA2 (0.51) | EGFRTNNI3KFBP1PGRKAT6A | |
| SCHEMBL14349613 | 0.71 | ALDH1A1 (0.54) | SMN1; SMN2CA2KDM4EMEN1LMNA | |
| SCHEMBL104506 | 0.70 | ALDH1A1 (0.58) | SMN1; SMN2KDM4ELMNAKMT2AHTR1A | |
| SCHEMBL25442623 | 0.70 | PGR (0.43) | EGFRTNNI3KFBP1PGRKAT6A | |
| SCHEMBL3300268 | 0.69 | LOXL2 (0.39) | EGFRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |