Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349870 | 0.85 | HCAR2 (0.63) | SMN1; SMN2LMNANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL14349872 | 0.85 | HCAR2 (0.56) | SMN1; SMN2LMNANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL14349878 | 0.83 | HCAR2 (0.52) | SMN1; SMN2HSD17B10ALDH1A1KMT2AACHE | |
| SCHEMBL7913431 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL4548382 | 0.73 | CYP1A2 (0.62) | SMN1; SMN2LMNANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL7911579 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL14349875 | 0.72 | HCAR2 (0.81) | HSD17B10KMT2AKDM4EMEN1ALPL | |
| SCHEMBL7916986 | 0.71 | ALDH1A1 (0.46) | SMN1; SMN2LMNANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL7903245 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL14349877 | 0.70 | HCAR2 (0.70) | ALDH1A1KMT2ATP53KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299101-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2007-12-27 | — | — | US | disclosed |
| US-20070299101-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299101-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | LDLR, APOB, FFAR1 | SMN1; SMN2 2600/4885LMNA 732/4885NPSR1 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.