SCHEMBL1435285

SCHEMBL1435285

O=C(O)c1ccc(CNC(=O)C(F)(F)F)cc1

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.61
NR1H4 Q96RI1 7/20 0.55
EPHX2 P34913 5/20 0.55
MMP8 P22894 1/20 0.54
ALDH1A1 P00352 2/20 0.50
SRD5A2 P31213 1/20 0.50
SELL P14151 1/20 0.49
SELP P16109 1/20 0.49
SELE P16581 1/20 0.49
MEN1 O00255 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30471275 0.83 RIPK1 (0.61) KMT2AMMP8ALDH1A1MEN1HDAC6
SCHEMBL4765237 0.83 RIPK1 (0.61) KMT2AMMP8ALDH1A1MEN1HDAC6
SCHEMBL3196978 0.83 MLYCD (0.54) KMT2AALDH1A1SRD5A2MEN1HDAC6
SCHEMBL15372391 0.83 EPHX2 (0.48) KMT2ANR1H4EPHX2ALDH1A1HDAC6
SCHEMBL12188585 0.82 HDAC6 (0.71) KMT2ANR1H4EPHX2MMP8ALDH1A1
SCHEMBL506307 0.81 MTOR (0.54) NR1H4EPHX2ALDH1A1HDAC6
SCHEMBL2054822 0.81 EPHX2 (0.50) KMT2ANR1H4EPHX2ALDH1A1MEN1
SCHEMBL8072288 0.81 LOXL2 (0.53) KMT2ANR1H4EPHX2ALDH1A1MEN1
SCHEMBL25295609 0.80 NR1H4 (0.58) KMT2ANR1H4ALDH1A1
SCHEMBL15013037 0.80 SMN1; SMN2 (0.56) KMT2ANR1H4EPHX2ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119462760-A Fluorescence-labeled ddNTP, synthesis method and application thereof, DNA sequencing kit and preparation method thereof 河北迪纳兴科生物科技有限公司 2025-02-18 CN claimed
EP-4631931-A1 HDAC INHIBITOR AND USE THEREOF Wigen Biomedicine Technology (Shanghai) Co., Ltd. (CN) 2025-10-15 EP disclosed
WO-2025041160-A1 BIFUNCTIONAL CONJUGATE MOLECULES FOR CANCER TREATMENT AND PROCESS OF MAKING THE SAME BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE (BITS), PILANI (IN) 2025-02-27 WO disclosed
CN-119462760-A Fluorescence-labeled ddNTP, synthesis method and application thereof, DNA sequencing kit and preparation method thereof 河北迪纳兴科生物科技有限公司 2025-02-18 CN disclosed
US-20240327418-A1 MULTI-TARGET INHIBITOR TARGETING HDAC AND NAD SYNTHESIS AND USE OF MULTI-TARGET INHIBITOR OCEAN UNIVERSITY OF CHINA (CN) 2024-10-03 US disclosed
US-20230160001-A1 NUCLEOTIDE CLEAVABLE LINKERS WITH RIGID SPACERS AND USES THEREOF FIRST-CITIZENS BANK & TRUST COMPANY 2023-05-25 US disclosed
US-20230137943-A1 PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS THE UNIVERSITY OF CHICAGO 2023-05-04 US disclosed
CN-115703736-A Multi-target inhibitors targeting HDAC and NAD synthesis and uses thereof 中国海洋大学 2023-02-17 CN disclosed
WO-2023011416-A1 MULTI-TARGET INHIBITOR TARGETING HDAC AND NAD SYNTHESIS AND USE OF MULTI-TARGET INHIBITOR 中国海洋大学 2023-02-09 WO disclosed
US-11400130-B2 Inhibitors for proliferating cell nuclear antigen and uses PURDUE RESEARCH FOUNDATION (US) 2022-08-02 US disclosed
US-20040147569-A1 Antitumor agents; autoimmune disease; skin disorders; anticancer agents SCHERING AKTIENGESELLSCHAFT 2004-07-29 US disclosed
WO-2004058234-A2 PHARMACEUTICAL COMBINATIONS OF PHTHALAZINE VEGF INHIBITORS AND BENZAMIDE HDAC INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 2004-07-15 WO disclosed
EP-1437346-A1 Benzamide derivatives useful as cell differentiation inducers Schering AG (DE) 2004-07-14 EP disclosed
EP-0847992-B1 Benzamide derivatives, useful as cell differentiation inducers SCHERING AG (DE) 2004-06-23 EP disclosed
EP-0923597-B1 SUBSTITUTED PROPARGYLETHOXYAMIDO NUCLEOSIDES PE CORP NY (US) 2001-09-26 EP disclosed
US-6174905-B1 AS CARCINOSTATIC AGENT TO A HEMATOLOGIC MALIGNANCY AND A SOLID CARCINOMA MITSUI CHEMICALS, INC. (JP) 2001-01-16 US disclosed
EP-0923597-A1 SUBSTITUTED PROPARGYLETHOXYAMIDO NUCLEOSIDES THE PERKIN-ELMER CORPORATION (US) 1999-06-23 EP disclosed
WO-1998045310-A1 SUBSTITUTED PROPARGYLETHOXYAMIDO NUCLEOSIDES THE PERKIN-ELMER CORPORATION (US) 1998-10-15 WO disclosed
US-5770716-A CHAIN TERMINATING AND CHAIN EXTENDING NUCLEOTIDES, PRIMER EXTENSION REACTIONS, DNA SEQUENCING, POLYMERASE CHAIN REACTION THE PERKIN-ELMER CORPORATION (US) 1998-06-23 US disclosed
EP-0847992-A1 Benzamide derivatives, useful as cell differentiation inducers Mitsui Chemicals, Inc. (JP) 1998-06-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040147569-A1 Antitumor agents; autoimmune disease; skin disorders; anticancer agents MCL1, MYADM, PDCD1 KMT2A 794/4885NR1H4 3610/4885EPHX2 3971/4885
US-11400130-B2 Inhibitors for proliferating cell nuclear antigen and uses MKI67, PCNA, PCLAF KMT2A 1025/4885NR1H4 1406/4885EPHX2 3869/4885
US-20240327418-A1 MULTI-TARGET INHIBITOR TARGETING HDAC AND NAD SYNTHESIS AND USE OF MULTI-TARGET INHIBITOR HDAC3, HDAC1, HDAC11 KMT2A 138/4885NR1H4 200/4885EPHX2 990/4885
US-20230137943-A1 PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS PPIA, S100A4, S100A6 KMT2A 3560/4885NR1H4 4505/4885EPHX2 3127/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.