Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143539 | 0.88 | CA12 (0.43) | MAPTHPGDALDH1A1KMT2ALMNA | |
| SCHEMBL143556 | 0.87 | MAPT (0.44) | MAPTHPGDALDH1A1KMT2ALMNA | |
| SCHEMBL147870 | 0.87 | MAPT (0.44) | MAPTHPGDALDH1A1KMT2ALMNA | |
| SCHEMBL9865883 | 0.86 | GAA (0.43) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL147476 | 0.85 | MAPT (0.43) | MAPTHPGDALDH1A1KMT2ALMNA | |
| Sulfuric Acid SCHEMBL141954 | 0.84 | KMT2A (0.38) | MAPTHPGDALDH1A1KMT2ALMNA | |
| Sulfuric Acid SCHEMBL141955 | 0.84 | KMT2A (0.38) | MAPTHPGDALDH1A1KMT2ALMNA | |
| SCHEMBL142529 | 0.83 | MAPT (0.42) | MAPTHPGDALDH1A1KMT2ALMNA | |
| SCHEMBL147386 | 0.83 | MAPT (0.42) | MAPTHPGDALDH1A1KMT2ALMNA | |
| SCHEMBL24352 | 0.83 | MAPT (0.49) | MAPTHPGDALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2263642-B1 | Colouring bleaches | HENKEL AG & CO KGAA (DE) | 2020-04-15 | — | — | EP | disclosed |
| EP-2306963-B1 | MATTING ADDITIVE FOR BLEACHING | HENKEL AG & CO KGAA (DE) | 2018-03-28 | — | — | EP | disclosed |
| EP-2271302-B1 | BLEACHING AGENT COMPRISING A CATIONIC ACYL PYRIDINIUM DERIVATIVE, A CO-BLEACHING ACTIVATOR, AND HYDROGEN PEROXIDE | HENKEL AG & CO KGAA (DE) | 2017-07-12 | — | — | EP | disclosed |
| US-9693937-B2 | Foil applicator | HENKEL AG & CO. KGAA (DE) | 2017-07-04 | — | — | US | disclosed |
| US-20150174019-A1 | FOIL APPLICATOR | HENKEL AG & CO. KGAA (DE) | 2015-06-25 | — | — | US | disclosed |
| EP-2427247-B1 | FOIL APPLICATOR | HENKEL AG & CO KGAA (DE) | 2013-12-18 | — | — | EP | disclosed |
| US-8137412-B2 | Bleaching with concomitant hair tonicizing | HENKEL AG & CO. KGAA (DE) | 2012-03-20 | — | — | US | disclosed |
| EP-2427247-A2 | FOIL APPLICATOR | Henkel AG & Co. KGaA (DE) | 2012-03-14 | — | — | EP | disclosed |
| US-20120055500-A1 | Foil Applicator | HENKEL AG & CO. KGAA (DE) | 2012-03-08 | — | — | US | disclosed |
| US-20110232669-A1 | Bleaching with Concomitant Hair Tonicizing | HENKEL AG & CO. KGAA (DE) | 2011-09-29 | — | — | US | disclosed |
| US-20110126361-A1 | Matting Additive for Blond Hair Dyeing | MANNECK HARTMUT | 2011-06-02 | — | — | US | disclosed |
| EP-2306963-A1 | MATTING ADDITIVE FOR BLOND HAIR DYING | Henkel AG & Co. KGaA (DE) | 2011-04-13 | — | — | EP | disclosed |
| US-20110047712-A1 | BLEACHING AGENT HAVING CATIONIC ACYL PYRIDINIUM DERATIVES, CO-BLEACHING ACTIVATORS AND HYDROGEN PEROXIDE | HENKEL AG & CO. KGAA (DE) | 2011-03-03 | — | — | US | disclosed |
| EP-2271302-A1 | BLEACHING AGENT HAVING CATIONIC ACYL PYRIDINIUM DERIVATIVES, CO-BLEACHING ACTIVATORS, AND HYDROGEN PEROXIDE | Henkel AG & Co. KGaA (DE) | 2011-01-12 | — | — | EP | disclosed |
| EP-2263642-A2 | Colouring bleaches | Henkel AG & Co. KGaA (DE) | 2010-12-22 | — | — | EP | disclosed |
| WO-2010127902-A2 | FOIL APPLICATOR | HENKEL AG & CO. KGAA (DE) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010066720-A2 | IMPROVED BEACHING WITH CONCOMITANT HAIR TONICIZING | HENKEL AG & CO. KGAA (DE) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010054981-A2 | COMBINATION OF CATIONIC BLEACH ACTIVATORS AND DYES | HENKEL AG & CO. KGAA (DE) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010015441-A1 | MATTING ADDITIVE FOR BLOND HAIR DYING | HENKEL AG & CO. KGAA (DE) | 2010-02-11 | — | — | WO | disclosed |
| WO-2009135700-A1 | BLEACHING AGENT HAVING CATIONIC ACYL PYRIDINIUM DERIVATIVES, CO-BLEACHING ACTIVATORS, AND HYDROGEN PEROXIDE | HENKEL AG & CO. KGAA (DE) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110047712-A1 | BLEACHING AGENT HAVING CATIONIC ACYL PYRIDINIUM DERATIVES, CO-BLEACHING ACTIVATORS AND HYDROGEN PEROXIDE | F12, KRT18, H1-3 | MAPT 3525/4885HPGD 1977/4885ALDH1A1 980/4885 |
| US-20110126361-A1 | Matting Additive for Blond Hair Dyeing | LDHB, HMBS, HBB | MAPT 2863/4885HPGD 836/4885ALDH1A1 2121/4885 |
| US-20110232669-A1 | Bleaching with Concomitant Hair Tonicizing | KRT18, KAT7, KAT2B | MAPT 1361/4885HPGD 2068/4885ALDH1A1 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.