Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 11/20 | 0.38 |
| ▸ | TUBB | P07437 | 11/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 11/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 11/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 11/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 11/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 11/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 11/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 11/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 11/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 11/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 11/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 11/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 11/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 11/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14358192 | 1.00 | TUBB4A (0.38) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3015223 | 0.78 | PDE4B (0.34) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3015219 | 0.78 | PDE4B (0.34) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL14486125 | 0.76 | DAO (0.50) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4C | |
| SCHEMBL14485919 | 0.76 | DAO (0.48) | KDM4C | |
| SCHEMBL14486392 | 0.75 | DAO (0.51) | ALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL9918615 | 0.75 | PTPN1 (0.36) | NPC1RAB9AKDM4CPDE4B | |
| SCHEMBL3166464 | 0.75 | PTPN1 (0.36) | NPC1RAB9AKDM4CPDE4BTGFBR1 | |
| SCHEMBL3016309 | 0.75 | DHFR (0.41) | NPC1RAB9AKDM4CPDE4BTGFBR1 | |
| SCHEMBL12046269 | 0.75 | KDM4C (0.37) | NPC1ALDH1A1RAB9AKDM4CPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243302-A1 | BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME CORPORATION (US) | 2014-08-28 | — | — | US | disclosed |
| EP-2723737-A1 | BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | Kyorin Pharmaceutical Co., Ltd. (JP) | 2014-04-30 | — | — | EP | disclosed |
| WO-2013003383-A1 | BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2013-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243302-A1 | BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | PAICS, SBDS, SORD | TUBB4A 907/4885TUBB 456/4885TUBA3C 812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.