Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724278 | 0.77 | HTR6 (0.61) | HTR6DRD2HTR2AHTR7CA12 | |
| SCHEMBL29728507 | 0.77 | HTR6 (0.61) | HTR6DRD2HTR2AHTR7CA12 | |
| SCHEMBL3644542 | 0.73 | HTR6 (1.00) | HTR6DRD2HTR2AHTR7CA12 | |
| SCHEMBL2466032 | 0.72 | HTR6 (0.62) | HTR6DRD2HTR2AHTR7L3MBTL1 | |
| SCHEMBL15909609 | 0.71 | HTR6 (0.46) | HTR6DRD2HTR2AHTR7CA12 | |
| SCHEMBL15135563 | 0.71 | TUBB4A (0.49) | HTR6DRD2HTR2AHTR7CA12 | |
| SCHEMBL14365336 | 0.70 | HTR6 (0.58) | HTR6DRD2HTR2AHTR7CA12 | |
| SCHEMBL14451017 | 0.70 | HTR6 (0.85) | HTR6DRD2HTR2AHTR7CA12 | |
| SCHEMBL724446 | 0.69 | HTR6 (0.65) | HTR6DRD2HTR2AHTR7CA12 | |
| SCHEMBL29728504 | 0.69 | HTR6 (0.65) | HTR6DRD2HTR2AHTR7CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542081-A1 | COMPOUNDS FOR TREATMENT OF CANCER | Gtx, Inc. (US) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011109059-A1 | COMPOUNDS FOR TREATMENT OF CANCER | GTX, INC. (US) | 2011-09-09 | — | — | WO | disclosed |