Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLI1 | P08151 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24359208 | 0.82 | CTSB (0.47) | CTSBCTSSCTSKEPHX1PSEN1 | |
| SCHEMBL24358985 | 0.82 | CTSB (0.47) | CTSBCTSSCTSKEPHX1PSEN1 | |
| SCHEMBL14366020 | 0.80 | PSEN1 (0.45) | EPHX1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12522714 | 0.79 | EPHX1 (0.48) | EPHX1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL13888656 | 0.79 | EPHX1 (0.48) | EPHX1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL12588569 | 0.79 | EPHX1 (0.48) | EPHX1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL12522719 | 0.79 | EPHX1 (0.48) | EPHX1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL13902258 | 0.77 | PSEN1 (0.45) | EPHX1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9005013 | 0.74 | CTSB (0.58) | CTSBCTSSCTSKEPHX1GLI1 | |
| SCHEMBL9005010 | 0.74 | CTSB (0.58) | CTSBCTSSCTSKEPHX1GLI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259855-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259855-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | ROR1, RORB, RORA | CTSB 4532/4885CTSS 4320/4885CTSK 3458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.