Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | HAAO | P46952 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.37 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257346 | 0.84 | RXRB (0.49) | MCL1HAAOALDH1A1KDM4EHPGD | |
| SCHEMBL14366362 | 0.81 | TDP1 (0.46) | ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13652578 | 0.79 | ALDH1A1 (0.48) | HAAOALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL23662320 | 0.78 | CA12 (0.47) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL14683982 | 0.78 | POLB (0.40) | KDM4EHPGDHSD17B10GAAPOLB | |
| SCHEMBL223101 | 0.77 | CSNK2A1 (0.65) | MCL1ALDH1A1KDM4EHPGDCSNK2A1 | |
| SCHEMBL70164 | 0.77 | MCL1 (0.66) | MCL1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL1334366 | 0.76 | CA12 (0.61) | MCL1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL6917333 | 0.76 | CSNK2A1 (0.63) | MCL1ALDH1A1KDM4EHPGDCSNK2A1 | |
| SCHEMBL6916095 | 0.76 | CSNK2A1 (0.63) | MCL1ALDH1A1KDM4ECSNK2A1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |