Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14366361 | 0.81 | MCL1 (0.43) | MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL13283441 | 0.80 | DGAT1 (0.41) | TDP1SIRT3MAPK1NNMTMEN1 | |
| SCHEMBL24201744 | 0.78 | ALDH1A1 (0.37) | TDP1SIRT3MAPK1NNMTMEN1 | |
| SCHEMBL1003845 | 0.78 | MEN1 (0.53) | TDP1SIRT3MAPK1SMN1; SMN2MEN1 | |
| SCHEMBL6825758 | 0.77 | PARP1 (0.50) | TDP1SIRT3MAPK1NNMTSMN1; SMN2 | |
| SCHEMBL328278 | 0.77 | CASP1 (0.50) | TDP1SIRT3MAPK1NNMTMEN1 | |
| Hydrochloric Acid SCHEMBL28266821 | 0.77 | MEN1 (0.52) | TDP1SIRT3MAPK1SMN1; SMN2MEN1 | |
| SCHEMBL4950195 | 0.77 | TDP1 (0.47) | TDP1SIRT3MAPK1NNMTSMN1; SMN2 | |
| SCHEMBL6128269 | 0.77 | KDM4E (0.50) | TDP1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL14683982 | 0.76 | POLB (0.40) | SMN1; SMN2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |