Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 6/20 | 0.39 |
| ▸ | KIT | P10721 | 6/20 | 0.39 |
| ▸ | BLK | P51451 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 11/20 | 0.35 |
| ▸ | ABL1 | P00519 | 8/20 | 0.35 |
| ▸ | SRC | P12931 | 7/20 | 0.35 |
| ▸ | FLT3 | P36888 | 6/20 | 0.35 |
| ▸ | FLT1 | P17948 | 5/20 | 0.35 |
| ▸ | FLT4 | P35916 | 5/20 | 0.35 |
| ▸ | LYN | P07948 | 4/20 | 0.35 |
| ▸ | LCK | P06239 | 4/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12973252 | 0.89 | MAPT (0.45) | CSF1RKITBLKHTTCFTR | |
| SCHEMBL2818604 | 0.75 | IKBKB (0.44) | CSF1RKITBLKHTTLMNA | |
| SCHEMBL30367366 | 0.74 | HTT (0.41) | CSF1RKITBLKHTTLMNA | |
| SCHEMBL2818684 | 0.70 | RAB9A (0.50) | HTTPOLBMAPT | |
| SCHEMBL2821619 | 0.69 | CSF1R (0.45) | CSF1RKITBLKHTTKDR | |
| SCHEMBL30585421 | 0.68 | HRH4 (0.47) | HTTLMNAMAPTIKBKBMAP4K4 | |
| SCHEMBL13329767 | 0.67 | LMNA (0.53) | HTTLMNAPOLBMAPTMKNK2 | |
| SCHEMBL2816137 | 0.67 | MEN1 (0.47) | LMNAPOLBMAPT | |
| SCHEMBL30585433 | 0.66 | ALDH1A1 (0.46) | HTTLMNAMAPTMAP4K4 | |
| SCHEMBL2819164 | 0.66 | CSF1R (0.40) | CSF1RKITBLKHTTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007144204-A1 | SUBSTITUTED AMINOPYRAZOLOPYRIDINES AND SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-21 | — | — | WO | disclosed |