Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 2/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14366808 | 0.89 | POLB (0.46) | NOTUMMAPTPKMALOX12CHRM4 | |
| SCHEMBL3930700 | 0.71 | TRPA1 (0.46) | MAPTALDH1A1 | |
| SCHEMBL3932377 | 0.71 | PKM (0.49) | MAPTPKMTP53ALDH1A1KDM4E | |
| SCHEMBL3931870 | 0.70 | PTGDR2 (0.49) | MAPTPKMPOLBALDH1A1 | |
| SCHEMBL17316810 | 0.70 | ITGB3 (0.51) | NOTUMITGB3ITGA2BCASRPOLB | |
| SCHEMBL17316631 | 0.70 | ITGB3 (0.51) | NOTUMITGB3ITGA2BCASRPOLB | |
| SCHEMBL17316620 | 0.70 | ITGB3 (0.51) | NOTUMITGB3ITGA2BCASRPOLB | |
| SCHEMBL3933429 | 0.69 | ATM (0.62) | MYCNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL3938376 | 0.68 | PTGDR2 (0.54) | MAPTPKM | |
| SCHEMBL3933383 | 0.68 | PTGDR2 (0.47) | PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |