Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14366806 | 0.89 | NOTUM (0.45) | POLBNOTUMCHRM4ALDH1A1MCL1 | |
| SCHEMBL3932377 | 0.83 | PKM (0.49) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3933560 | 0.73 | THRB (0.44) | SMN1; SMN2ALDH1A1MAPTKMT2ATDP1 | |
| SCHEMBL14366366 | 0.72 | PKM (0.49) | POLBMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL3936577 | 0.72 | SLC7A5 (0.41) | POLBALDH1A1MAPTPKM | |
| SCHEMBL3942799 | 0.72 | NPC1 (0.55) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL14172860 | 0.71 | RAB9A (0.51) | POLBSMN1; SMN2CHRM4ALDH1A1MCL1 | |
| SCHEMBL3941870 | 0.71 | PKM (0.55) | MAPTMEN1KMT2AL3MBTL1PKM | |
| SCHEMBL3933544 | 0.71 | RAB9A (0.53) | POLBSMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL14190853 | 0.70 | ALDH1A1 (0.48) | POLBSMN1; SMN2CHRM4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |