Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18427275 | 0.83 | LTA4H (0.46) | LTA4HLMNAJAK2JAK1TYK2 | |
| SCHEMBL4437203 | 0.83 | LTA4H (0.49) | KDM4ETDP1LTA4HHRH4JAK2 | |
| SCHEMBL17865300 | 0.81 | LTA4H (0.48) | KDM4ETDP1LTA4HHRH4JAK2 | |
| SCHEMBL13940676 | 0.81 | LTA4H (0.40) | LTA4HJAK2JAK1TYK2JAK3 | |
| SCHEMBL9979865 | 0.79 | ALDH1A1 (0.60) | DRD4DRD3JAK2JAK1TYK2 | |
| SCHEMBL207529 | 0.79 | ALDH1A1 (0.47) | TDP1LTA4HLMNAJAK2JAK1 | |
| SCHEMBL12767170 | 0.77 | ALDH1A1 (0.43) | LTA4HJAK2JAK1TYK2JAK3 | |
| SCHEMBL209854 | 0.77 | ARG1 (0.42) | KDM4ETDP1ALDH1A1SRPK1 | |
| SCHEMBL9976594 | 0.76 | TLR8 (0.44) | LTA4HJAK2JAK1TYK2JAK3 | |
| SCHEMBL12424273 | 0.76 | JAK2 (0.36) | LTA4HJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297793-B2 | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors | G.D. SEARLE, LLC (US) | 2007-11-20 | — | — | US | disclosed |
| US-7297793-B2 | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors | G.D. SEARLE, LLC (US) | 2007-11-20 | — | — | US | disclosed |