Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | ARG1 | P05089 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437203 | 0.98 | LTA4H (0.49) | LTA4HHRH3CHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL18427275 | 0.94 | LTA4H (0.46) | LTA4HHRH3CHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL13940676 | 0.84 | LTA4H (0.40) | LTA4HALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL14367254 | 0.81 | KDM4E (0.47) | LTA4HALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL207529 | 0.81 | ALDH1A1 (0.47) | LTA4HHRH3ALDH1A1JAK2JAK1 | |
| SCHEMBL9979865 | 0.79 | ALDH1A1 (0.60) | HRH3ALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL15014625 | 0.79 | PARG (0.37) | LTA4HALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL12767170 | 0.76 | ALDH1A1 (0.43) | LTA4HHRH3SMN1; SMN2ALDH1A1JAK2 | |
| SCHEMBL209854 | 0.76 | ARG1 (0.42) | SMN1; SMN2ALDH1A1KDM4EHTTTDP1 | |
| SCHEMBL12727195 | 0.75 | ALDH1A1 (0.42) | LTA4HALDH1A1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016099394-A1 | NOVEL SELECTIVE DELTA-OPIOID RECEPTOR AGONISTS USEFUL FOR THE TREATMENT OF PAIN, ANXIETY AND DEPRESSION. | PHARMNOVO AB (SE) | 2016-06-23 | — | — | WO | disclosed |
| CN-100422151-C | Diarylmethylidene piperidine derivatives, their preparation and their use | ASTRAZENECA AB (SE) | 2008-10-01 | — | — | CN | disclosed |
| CN-1738801-A | Diarylmethylidene piperidine derivatives, their preparation and their use | ASTRAZENECA AB (SE) | 2006-02-22 | — | — | CN | disclosed |