Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927266 | 0.88 | MCL1 (0.49) | MCL1TRPV1 | |
| SCHEMBL3932024 | 0.85 | VEGFA (0.51) | VEGFAEGLN1GLSCHRM2CHRM4 | |
| SCHEMBL2475088 | 0.82 | HTR7 (0.53) | VEGFAEGLN1CD274ACKR3CHRM2 | |
| SCHEMBL30420918 | 0.82 | HTR7 (0.53) | VEGFAEGLN1CD274ACKR3CHRM2 | |
| SCHEMBL25217296 | 0.81 | VEGFA (0.52) | VEGFAEGLN1GLSCHRM2CHRM4 | |
| SCHEMBL3939019 | 0.79 | GLS (0.43) | VEGFAEGLN1GLSCHRM2CHRM4 | |
| SCHEMBL14367471 | 0.77 | NPSR1 (0.43) | VEGFAEGLN1GLSGPR119 | |
| SCHEMBL11932534 | 0.77 | FAAH (0.57) | VEGFAEGLN1ACKR3CHRM2CHRM4 | |
| SCHEMBL7921705 | 0.76 | IDO1 (0.47) | VEGFAEGLN1ACKR3CHRM2CHRM4 | |
| SCHEMBL30834665 | 0.75 | VEGFA (0.56) | VEGFAEGLN1RORCCHRM1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |