Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 3/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3937537 | 0.85 | ALDH1A1 (0.49) | ALDH1A1GAAGFERSMN1; SMN2LMNA | |
| SCHEMBL25217296 | 0.85 | VEGFA (0.52) | VEGFAEGLN1ALDH1A1GLSCHRM2 | |
| SCHEMBL14367476 | 0.85 | VEGFA (0.45) | VEGFAEGLN1GLSCHRM2CHRM4 | |
| SCHEMBL14367471 | 0.81 | NPSR1 (0.43) | VEGFAEGLN1ALDH1A1CA12CA1 | |
| SCHEMBL3939019 | 0.81 | GLS (0.43) | VEGFAEGLN1ALDH1A1CA12CA1 | |
| SCHEMBL4505464 | 0.81 | VEGFA (0.61) | VEGFAEGLN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL27539906 | 0.79 | VEGFA (0.53) | VEGFAEGLN1ALDH1A1CA12CA1 | |
| SCHEMBL18021941 | 0.79 | VEGFA (0.48) | VEGFAEGLN1ALDH1A1CA12CA1 | |
| SCHEMBL14367070 | 0.78 | ALDH1A1 (0.49) | ALDH1A1GAAGFERSMN1; SMN2MAPT | |
| SCHEMBL1668509 | 0.78 | JAK2 (0.45) | ALDH1A1GAAGFERSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |