Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGIR | P43119 | 2/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BAD | Q92934 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14367870 | 1.00 | ALDH1A1 (0.41) | ALDH1A1KDM4EGAAPTGIRTBXA2R | |
| SCHEMBL23865462 | 0.83 | DRD2 (0.40) | ALDH1A1KDM4EGAAPTGIRTBXA2R | |
| SCHEMBL10264290 | 0.83 | DRD2 (0.40) | ALDH1A1KDM4EGAAPTGIRTBXA2R | |
| SCHEMBL6101026 | 0.80 | CHRM2 (0.41) | ALDH1A1KDM4EGAAPTGIRTBXA2R | |
| SCHEMBL11395137 | 0.80 | CHRM2 (0.41) | ALDH1A1KDM4EGAAPTGIRTBXA2R | |
| SCHEMBL25540044 | 0.80 | MTNR1A (0.40) | ALDH1A1KDM4EGAAAKT1MTNR1A | |
| SCHEMBL11387073 | 0.80 | CHRM2 (0.38) | PTGIRTBXA2RCHRM2CHRM4CHRM1 | |
| SCHEMBL11393893 | 0.80 | CHRM2 (0.38) | ALDH1A1PTGIRTBXA2RCHRM2CHRM4 | |
| SCHEMBL6102422 | 0.80 | CHRM2 (0.41) | ALDH1A1KDM4EGAAPTGIRTBXA2R | |
| SCHEMBL12060494 | 0.77 | MTNR1A (0.40) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291644-B2 | Indole derivatives | ONO PHARMACEUTICALS CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |
| US-7291644-B2 | Indole derivatives | ONO PHARMACEUTICALS CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |