Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14263999 | 0.82 | HTR1B (0.73) | HTR1BKCNH2RAD52L3MBTL1ALDH1A1 | |
| SCHEMBL5354642 | 0.82 | HTR1B (0.73) | HTR1BKCNH2RAD52L3MBTL1ALDH1A1 | |
| SCHEMBL14370170 | 0.82 | HTR1B (0.73) | HTR1BKCNH2RAD52L3MBTL1ALDH1A1 | |
| SCHEMBL14370221 | 0.81 | HTR1B (0.57) | HTR1BKCNH2RAD52L3MBTL1ALDH1A1 | |
| SCHEMBL14264000 | 0.81 | HTR1B (0.57) | HTR1BKCNH2RAD52L3MBTL1ALDH1A1 | |
| SCHEMBL5308451 | 0.74 | HTR1B (0.78) | HTR1BKCNH2RAD52L3MBTL1ALDH1A1 | |
| SCHEMBL4806699 | 0.74 | ALDH1A1 (0.54) | HTR1BKCNH2RAD52L3MBTL1ALDH1A1 | |
| SCHEMBL5308358 | 0.73 | HTR1B (0.79) | HTR1BKCNH2RAD52ALDH1A1NPC1 | |
| SCHEMBL22411172 | 0.73 | HTR1B (0.57) | HTR1BKCNH2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL4247675 | 0.71 | HTR1B (1.00) | HTR1BKCNH2RAD52ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053093-A1 | CHROMAN COMPOUNDS AS 5 HT1B ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |