Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1744485 | 0.86 | LMNA (0.32) | LMNAKDM4EMAPK1MEN1KMT2A | |
| SCHEMBL1743968 | 0.83 | SIGMAR1 (0.31) | KDM4E | |
| SCHEMBL15673479 | 0.74 | PSMB1 (0.36) | KDM4EKMT2A | |
| SCHEMBL525991 | 0.74 | KDM4E (0.38) | KDM4EMAPK1MEN1KMT2A | |
| SCHEMBL526819 | 0.73 | F2 (0.31) | — | |
| SCHEMBL1437455 | 0.70 | LMNA (0.34) | LMNAKDM4EMAPT | |
| SCHEMBL18900347 | 0.66 | LTA4H (0.46) | — | |
| SCHEMBL18900144 | 0.64 | LTA4H (0.42) | — | |
| SCHEMBL944962 | 0.64 | MEN1 (0.30) | MEN1KMT2A | |
| SCHEMBL12537497 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470547-B1 | CONJUGATES OF PYRROLO[1,4]BENZODIAZEPINE DIMERS AS ANTICANCER AGENTS | SANOFI SA (FR) | 2014-05-14 | — | — | EP | disclosed |
| EP-2470547-A1 | CONJUGATES OF PYRROLO[1,4]BENZODIAZEPINE DIMERS AS ANTICANCER AGENTS | SANOFI (FR) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011023883-A1 | CONJUGATES OF PYRROLO[1,4]BENZODIAZEPINE DIMERS AS ANTICANCER AGENTS | SANOFI-AVENTIS (FR) | 2011-03-03 | — | — | WO | disclosed |