Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.60 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13215732 | 0.81 | ALDH1A1 (0.57) | HRH3SPHK2MAPK1ALDH1A1CRHBP | |
| SCHEMBL9893059 | 0.81 | MAPK1 (0.56) | SPHK2MAPK1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL3572935 | 0.80 | ALDH1A1 (0.60) | HRH3SPHK2MAPK1ALDH1A1CRHBP | |
| SCHEMBL9892993 | 0.80 | MAPK1 (0.55) | SPHK2MAPK1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL25824759 | 0.80 | MAPK1 (0.55) | HRH3SPHK2MAPK1ALDH1A1CRHBP | |
| SCHEMBL14395220 | 0.80 | MAPK1 (0.54) | SPHK2MAPK1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL11990426 | 0.80 | MAPK1 (0.54) | SPHK2MAPK1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL22549599 | 0.78 | MAPK1 (0.52) | HRH3SPHK2MAPK1ALDH1A1CRHBP | |
| SCHEMBL7360051 | 0.78 | HSD11B1 (0.51) | HRH3SPHK2HSD11B1DRD4TMEM97 | |
| SCHEMBL7852374 | 0.77 | MAPK1 (0.62) | SPHK2MAPK1ALDH1A1CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070244133-A1 | Thienopyrimidines and Thiazolopyrimidines for Use in Medicine | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | disclosed |
| US-20070244133-A1 | Thienopyrimidines and Thiazolopyrimidines for Use in Medicine | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244133-A1 | Thienopyrimidines and Thiazolopyrimidines for Use in Medicine | CXCR4, CXCR1, CXCR3 | HRH3 418/4885SPHK2 838/4885MAPK1 1616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.