Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 8/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.35 |
| ▸ | SRC | P12931 | 5/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 4/20 | 0.33 |
| ▸ | HCK | P08631 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 3/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.32 |
| ▸ | PRKDC | P78527 | 2/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17658859 | 0.84 | TSHR (0.34) | MPOSRCABL1TSHR | |
| SCHEMBL21241140 | 0.75 | HTT (0.36) | HTT | |
| SCHEMBL20284327 | 0.73 | ALDH1A1 (0.39) | SRCTSHR | |
| SCHEMBL20284331 | 0.73 | MPO (0.36) | MPOSRCHTT | |
| SCHEMBL9974272 | 0.71 | MPO (0.32) | MPO | |
| SCHEMBL20284329 | 0.71 | SRC (0.41) | MPOSRCTSHRPIK3CA | |
| SCHEMBL9941672 | 0.69 | CYP1A2 (0.45) | — | |
| SCHEMBL2622408 | 0.69 | LMNA (0.40) | TSHR | |
| SCHEMBL19557941 | 0.68 | NOS3 (0.35) | MPO | |
| SCHEMBL12419716 | 0.67 | NOS3 (0.34) | PDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279474-B2 | Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF) | GLAXO GROUP LIMITED (GB) | 2007-10-09 | — | — | US | disclosed |