Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | ME2 | P23368 | 1/20 | 0.46 |
| ▸ | ME1 | P48163 | 1/20 | 0.46 |
| ▸ | ME3 | Q16798 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349471 | 0.89 | PPARA (0.49) | PPARASIGMAR1SMN1; SMN2LMNAPRKAA2 | |
| SCHEMBL26501811 | 0.81 | PPARG (0.55) | PPARASMN1; SMN2LMNAPPARGPPARD | |
| SCHEMBL2744316 | 0.80 | LMNA (0.47) | PPARASMN1; SMN2LMNAPPARGPPARD | |
| SCHEMBL8931727 | 0.80 | SIGMAR1 (0.64) | PPARASIGMAR1LMNARETRAB9A | |
| SCHEMBL14349615 | 0.77 | KDM4E (0.52) | PPARASMN1; SMN2LMNAPPARGPPARD | |
| SCHEMBL27739973 | 0.75 | OPRM1 (0.68) | PPARASMN1; SMN2LMNAPRKAA2PPARG | |
| SCHEMBL19285228 | 0.75 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2LMNADRD2CHKA | |
| SCHEMBL20804352 | 0.75 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2LMNADRD2CHKA | |
| SCHEMBL1043952 | 0.75 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2LMNADRD2CHKA | |
| SCHEMBL12412677 | 0.74 | HSD11B1 (0.48) | PPARASMN1; SMN2LMNAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |