SCHEMBL1437695

SCHEMBL1437695

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1cccnc1)C(=O)CO

nearest known ligand 0.70

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 18/20 0.70
MMP1 P03956 17/20 0.70
PGR P06401 4/20 0.69
MEN1 O00255 1/20 0.69
USP2 O75604 1/20 0.69
CYP3A4 P08684 1/20 0.69
KMT2A Q03164 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7812 0.91 NR3C1 (0.73) NR3C1MMP1PGRMEN1USP2
Betamethasone Benzoate SCHEMBL11878006 0.91 NR3C1 (0.77) NR3C1MMP1PGRMEN1USP2
Betamethasone Benzoate SCHEMBL11877997 0.91 NR3C1 (0.77) NR3C1MMP1PGRMEN1USP2
Betamethasone Benzoate SCHEMBL49469 0.91 NR3C1 (0.77) NR3C1MMP1PGRMEN1USP2
Betamethasone Benzoate SCHEMBL2954925 0.91 NR3C1 (0.77) NR3C1MMP1PGRMEN1USP2
Betamethasone Benzoate SCHEMBL21682645 0.90 NR3C1 (0.77) NR3C1MMP1PGRMEN1USP2
SCHEMBL4102916 0.86 NR3C1 (0.72) NR3C1MMP1PGRMEN1USP2
SCHEMBL11037864 0.86 NR3C1 (0.72) NR3C1MMP1PGRMEN1USP2
Betamethasone Benzoate SCHEMBL6898101 0.86 NR3C1 (0.88) NR3C1MMP1PGRMEN1USP2
SCHEMBL6986508 0.86 NR3C1 (0.83) NR3C1MMP1PGRMEN1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024133513-A1 COMPOSITION AND PRODUCTS COMPRISING AN ANTIBIOTIC AND A GLUCOCORTICOID FOR TREATING MASTITIS VIRBAC (FR) 2024-06-27 WO disclosed
US-20240016818-A1 NOVEL USE OF GLUCOCORTICOIDS FOR THE TREATMENT OF EPITHELIAL MICROBIAL INFECTIONS OF A FLUID CONTAINING ORGAN WITH A NATURAL EXTERIOR ORIFICE IN MAMMALS VIRBAC (FR) 2024-01-18 US disclosed
US-11819506-B2 Use of glucocorticoids for the treatment of epithelial microbial infections of a fluid containing organ with a natural exterior orifice in mammals VIRBAC (FR) 2023-11-21 US disclosed
US-20220008439-A1 NOVEL USE OF GLUCOCORTICOIDS FOR THE TREATMENT OF EPITHELIAL MICROBIAL INFECTIONS OF A FLUID CONTAINING ORGAN WITH A NATURAL EXTERIOR ORIFICE IN MAMMALS VIRBAC (FR) 2022-01-13 US disclosed
US-20210386758-A1 TOPICAL FORMULATIONS COMPRISING A STEROID PRIMUS PHARMACEUTICALS, INC. (US) 2021-12-16 US disclosed
US-11179465-B2 Topical compositions comprising a corticosteroid PRIMUS PHARMACEUTICALS, INC. (US) 2021-11-23 US disclosed
EP-3829591-A1 NOVEL USE OF GLUCOCORTICOIDS FOR THE TREATMENT OF EPITHELIAL MICROBIAL INFECTIONS OF A FLUID CONTAINING ORGAN WITH A NATURAL EXTERIOR ORIFICE IN MAMMALS VIRBAC (FR) 2021-06-09 EP disclosed
CN-112512528-A Novel use of glucocorticoids for treating epithelial microbial infections of fluid-containing organs with natural exterior orifice in mammals 维克公司 2021-03-16 CN disclosed
US-20210069214-A1 TOPICAL COMPOSITIONS COMPRISING A CORTICOSTEROID FOR THE TREATMENT OF PSORIASIS IN PEDIATRIC PATIENTS ENCORE DERMATOLOGY, INC. (US) 2021-03-11 US disclosed
WO-2021046444-A1 TOPICAL COMPOSITIONS COMPRISING A CORTICOSTEROID FOR THE TREATMENT OF PSORIASIS IN PEDIATRIC PATIENTS ENCORE DERMATOLOGY, INC. (US) 2021-03-11 WO disclosed
US-20160235767-A1 TOPICAL FORMULATIONS COMPRISING A STEROID PRIMUS PHARMACEUTICALS, INC. 2016-08-18 US disclosed
US-20160199493-A1 TOPICAL COMPOSITIONS COMPRISING A CORTICOSTEROID PRIMUS PHARMACEUTICALS, INC. 2016-07-14 US disclosed
US-20160184431-A1 TOPICAL COMPOSITIONS COMPRISING A CORTICOSTEROID PROMIUS PHARMA LLC (US) 2016-06-30 US disclosed
US-9364485-B2 Topical formulations comprising a steroid DR. REDDY'S LABORATORIES LTD. (IN) 2016-06-14 US disclosed
US-20160030450-A1 TOPICAL CORTICOSTEROID COMPOSITIONS PROMIUS PHARMA LLC 2016-02-04 US disclosed
US-20150258119-A1 TOPICAL CORTICOSTEROID COMPOSITIONS Promius Pharma, LLC 2015-09-17 US disclosed
WO-2015138650-A1 TOPICAL CORTICOSTEROID COMPOSITIONS Promius Pharma, LLC (US) 2015-09-17 WO disclosed
US-20120214776-A1 TOPICAL FORMULATIONS COMPRISING A STEROID DR. REDDY'S LABORATORIES, INC. (US) 2012-08-23 US disclosed
EP-2473161-A2 TOPICAL FORMULATIONS COMPRISING A STEROID Dr. Reddy's Laboratories Ltd. (IN) 2012-07-11 EP disclosed
WO-2011026076-A2 TOPICAL FORMULATIONS COMPRISING A STEROID DR. REDDY'S LABORATORIES LTD. (IN) 2011-03-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160030450-A1 TOPICAL CORTICOSTEROID COMPOSITIONS NR5A1, NR3C1, SERPINA6 NR3C1 2/4885MMP1 155/4885PGR 597/4885
US-20210069214-A1 TOPICAL COMPOSITIONS COMPRISING A CORTICOSTEROID FOR THE TREATMENT OF PSORIASIS IN PEDIATRIC PATIENTS TSLP, IL17A, IL5 NR3C1 7/4885MMP1 504/4885PGR 420/4885
US-20160235767-A1 TOPICAL FORMULATIONS COMPRISING A STEROID NR5A1, CYP17A1, TSLP NR3C1 11/4885MMP1 289/4885PGR 233/4885
US-11179465-B2 Topical compositions comprising a corticosteroid NR5A1, NR3C1, CYP17A1 NR3C1 2/4885MMP1 65/4885PGR 442/4885
US-20160199493-A1 TOPICAL COMPOSITIONS COMPRISING A CORTICOSTEROID NR3C1, NR5A1, TSLP NR3C1 1/4885MMP1 76/4885PGR 74/4885
US-20210386758-A1 TOPICAL FORMULATIONS COMPRISING A STEROID NR5A1, CYP17A1, TSLP NR3C1 11/4885MMP1 289/4885PGR 233/4885
US-20120214776-A1 TOPICAL FORMULATIONS COMPRISING A STEROID NR5A1, CYP17A1, TSLP NR3C1 11/4885MMP1 289/4885PGR 233/4885
US-20160184431-A1 TOPICAL COMPOSITIONS COMPRISING A CORTICOSTEROID NR3C1, NR5A1, TSLP NR3C1 1/4885MMP1 76/4885PGR 74/4885
US-20150258119-A1 TOPICAL CORTICOSTEROID COMPOSITIONS NR5A1, NR3C1, NR3C2 NR3C1 2/4885MMP1 192/4885PGR 435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.